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Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

• See also

• External links

• References

• Terminal complement pathway deficiency

• Complement+C7 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.

cite-note-refgrch38ensembl-11. GRCh38: Ensembl release 89: ENSG00000112936 – Ensembl, May 2017

cite-note-refgrcm38ensembl-22. GRCm38: Ensembl release 89: ENSMUSG00000079105 – Ensembl, May 2017

cite-note-33. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

cite-note-44. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.